# HG changeset patch # User bshanks@bshanks-salk.dyndns.org # Date 1239503708 25200 # Node ID 7487ad7f5d8f7e18b10984d0536f046f571fa459 # Parent 29eee29f9bc1b34182a6c0ebe5d596ff9b5e5684 . --- a/.hgignore Sat Apr 11 19:12:32 2009 -0700 +++ b/.hgignore Sat Apr 11 19:35:08 2009 -0700 @@ -14,6 +14,7 @@ *.aux *.xref *.lg +*.4?? syntax: regexp .*\#.*\#$ --- a/grant.html Sat Apr 11 19:12:32 2009 -0700 +++ b/grant.html Sat Apr 11 19:35:08 2009 -0700 @@ -108,12 +108,12 @@ to label more than a few genes. Therefore, we must select only a few genes as features. Principle 3: Use geometry in feature selection - When doing feature selection with score-based methods, the simplest thing to - do would be to score the performance of each voxel by itself and then combine - these scores; this is pointwise scoring. A more powerful approach is to also use - information about the geometric relations between each voxel and its neighbors; - this requires non-pointwise, local scoring methods. See Preliminary Results for - evidence of the complementary nature of pointwise and local scoring methods. + When doing feature selection with score-based methods, the simplest thing to do + would be to score the performance of each voxel by itself and then combine these + scores (pointwise scoring). A more powerful approach is to also use information + about the geometric relations between each voxel and its neighbors; this requires + non-pointwise, local scoring methods. See Preliminary Results for evidence of + the complementary nature of pointwise and local scoring methods. Principle 4: Work in 2-D whenever possible There are many anatomical structures which are commonly characterized in terms of a two-dimensional manifold. When it is known that the structure that @@ -121,6 +121,8 @@ the analysis algorithm to take advantage of this prior knowledge. In addition, it is easier for humans to visualize and work with 2-D data. Therefore, when possible, the instances should represent pixels, not voxels. + Aim 2 + todo 3 Aim 3 @@ -173,6 +175,7 @@ conceivable that the methods we propose to develop could be used to suggest modifications to the human cortical map as well. Related work + todo Preliminary work Justification of principles 1 thur 3 Principle 1: Combinatorial gene expression @@ -198,8 +201,6 @@ useful. The requirement to find combinations of only a small number of genes limits us from straightforwardly applying many of the most simple techniques from - the field of supervised machine learning. In the parlance of machine learning, - our task combines feature selection with supervised learning. __________________________ 1“WW, C2 and coiled-coil domain containing 1”; EntrezGene ID 211652 2“mitochondrial translational initiation factor 2”; EntrezGene ID 76784 @@ -228,6 +229,8 @@ genes which (individually) best match area AUD, according to gradient similar- ity. From left to right and top to bottom, the genes are Ssr1, Efcbp1, Aph1a, Ptk7, Aph1a again, and Lepr + the field of supervised machine learning. In the parlance of machine learning, + our task combines feature selection with supervised learning. Principle 3: Use geometry To show that local geometry can provide useful information that cannot be detected via pointwise analyses, consider Fig. . The top row of Fig. displays Binary file grant.odt has changed Binary file grant.pdf has changed