1.1 --- a/grant.txt Wed Apr 22 22:24:24 2009 -0700 1.2 +++ b/grant.txt Thu Apr 23 03:12:36 2009 -0700 1.3 @@ -48,8 +48,7 @@ 1.4 \newpage 1.5 1.6 == Analysis of high dimensional data for genomic anatomy in the brain == 1.7 - 1.8 -This proposal addresses challenge topic 06-HG-101. Massive new datasets obtained with techniques such as in situ hybridization (ISH), immunohistochemistry, in situ transgenic reporter, microarray voxelation, and others, allow the expression levels of many genes at many locations to be compared. Our goal is to develop automated methods to relate spatial variation in gene expression to anatomy. We want to find marker genes for specific anatomical regions, and also to draw new anatomical maps based on gene expression patterns. 1.9 +This application addresses broad Challenge Area (06) __Enabling Technologies__ and specific Challenge Topic, 06-HG-101: __New computational and statistical methods for the analysis of large data sets from next-generation sequencing technologies__. Massive new datasets obtained with techniques such as in situ hybridization (ISH), immunohistochemistry, in situ transgenic reporter, microarray voxelation, and others, allow the expression levels of many genes at many locations to be compared. Our goal is to develop automated methods to relate spatial variation in gene expression to anatomy. We want to find marker genes for specific anatomical regions, and also to draw new anatomical maps based on gene expression patterns. 1.10 1.11 \vspace{0.3cm}\hrule 1.12 == The Challenge and Potential impact ==