1.1 --- a/grant.txt Tue Apr 21 05:50:39 2009 -0700 1.2 +++ b/grant.txt Tue Apr 21 05:58:31 2009 -0700 1.3 @@ -531,7 +531,7 @@ 1.4 1.5 == Timeline and milestones == 1.6 1.7 -=== Aim 1 === 1.8 +=== Finding marker genes === 1.9 1.10 * September-November 2009: Develop an automated mechanism for segmenting the cortical voxels into layers 1.11 * November 2009 (milestone): Have completed construction of a flatmapped, cortical dataset with information for each layer 1.12 @@ -541,7 +541,7 @@ 1.13 * June 2010 (milestone): Submit a paper describing a method fulfilling Aim 1. Release toolbox. 1.14 * July 2010 (milestone): Submit a paper describing combinations of marker genes for each cortical area, and a small number of marker genes that can, in combination, define most of the areas at once 1.15 1.16 -=== Aim 2 === 1.17 +=== Revealing new ways to parcellate a structure into regions === 1.18 * April-March 2011: Explore dimensionality reduction algorithms for Aim 2. Explore standard hierarchial clustering algorithms, used in combination with dimensionality reduction, for Aim 2. Explore co-clustering algorithms. Think about how radial profile information can be used for Aim 2. Adapt clustering algorithms to use radial profile information. Quantitatively compare the performance of different dimensionality reduction and clustering techniques. Quantitatively compare the value of different flatmapping methods and ways of representing radial profiles. 1.19 * March 2011 (milestone): Submit a paper describing a method fulfilling Aim 2. Release toolbox. 1.20 * February-May 2011: Using the methods developed for Aim 2, explore the genomic anatomy of the cortex. If new ways of organizing the cortex into areas are discovered, read the literature and talk to people to learn about research related to interpreting our results. Create documentation and unit tests for software toolbox for Aim 2. Respond to user bug reports for Aim 2 software toolbox.