1.1 --- a/grant.html Tue Apr 21 05:50:39 2009 -0700 1.2 +++ b/grant.html Tue Apr 21 05:58:31 2009 -0700 1.3 @@ -643,7 +643,7 @@ 1.4 developed in Aim 2, we will present one or more hierarchial cortical maps. We will identify and explain how the statistical 1.5 structure in the gene expression data led to any unexpected or interesting features of these maps. 1.6 Timeline and milestones 1.7 -Aim 1 1.8 +Finding marker genes 1.9 ∙September-November 2009: Develop an automated mechanism for segmenting the cortical voxels into layers 1.10 ∙November 2009 (milestone): Have completed construction of a flatmapped, cortical dataset with information for each 1.11 layer 1.12 @@ -660,7 +660,7 @@ 1.13 ∙June 2010 (milestone): Submit a paper describing a method fulfilling Aim 1. Release toolbox. 1.14 ∙July 2010 (milestone): Submit a paper describing combinations of marker genes for each cortical area, and a small 1.15 number of marker genes that can, in combination, define most of the areas at once 1.16 -Aim 2 1.17 +Revealing new ways to parcellate a structure into regions 1.18 ∙April-March 2011: Explore dimensionality reduction algorithms for Aim 2. Explore standard hierarchial clustering 1.19 algorithms, used in combination with dimensionality reduction, for Aim 2. Explore co-clustering algorithms. Think 1.20 about how radial profile information can be used for Aim 2. Adapt clustering algorithms to use radial profile in- 1.21 @@ -670,7 +670,7 @@ 1.22 ∙February-May 2011: Using the methods developed for Aim 2, explore the genomic anatomy of the cortex. If new ways 1.23 of organizing the cortex into areas are discovered, read the literature and talk to people to learn about research related 1.24 to interpreting our results. Create documentation and unit tests for software toolbox for Aim 2. Respond to user bug 1.25 -reports for Aim 1 software toolbox. 1.26 +reports for Aim 2 software toolbox. 1.27 ∙May 2011 (milestone): Submit a paper on the genomic anatomy of the cortex, using the methods developed in Aim 2 1.28 ∙May-August 2011: Revisit Aim 1 to see if what was learned during Aim 2 can improve the methods for Aim 1. Follow 1.29 up on responses to our papers. Possibly submit another paper.