1.1 --- a/grant.html Mon Apr 20 17:11:38 2009 -0700 1.2 +++ b/grant.html Mon Apr 20 17:13:37 2009 -0700 1.3 @@ -364,8 +364,7 @@ 1.4 1.5 Figure 2: Gene Pitx2 1.6 is selectively underex- 1.7 -pressed in area SS (so- 1.8 -matosensory). We created a normalized version of the gene expression data by subtracting each gene’s mean 1.9 +pressed in area SS. We created a normalized version of the gene expression data by subtracting each gene’s mean 1.10 expression level (over all surface pixels) and dividing each gene by its standard deviation. 1.11 The features and the target area are both functions on the surface pixels. They can be referred 1.12 to as scalar fields over the space of surface pixels; alternately, they can be thought of as images 1.13 @@ -378,7 +377,7 @@ 1.14 In the Research Plan, we describe how we will automatically locate the layer depths. For 1.15 validation, we have manually demarcated the depth of the outer boundary of cortical layer 5 1.16 throughout the cortex. 1.17 - Feature selection and scoring methods 1.18 +Feature selection and scoring methods 1.19 Underexpression of a gene can serve as a marker Underexpression of a gene can sometimes serve as a marker. See, 1.20 for example, Figure 2. 1.21 Correlation Recall that the instances are surface pixels, and consider the problem of attempting to classify each instance 1.22 @@ -471,9 +470,9 @@ 1.23 1.24 Figure 5: From left to right and top to bot- 1.25 tom, single genes which roughly identify ar- 1.26 -eas SS (somatosensory primary +supplemental), 1.27 -SSs (supplemental somatosensory), PIR (piri- 1.28 -form), FRP (frontal pole), RSP (retrosplenial), 1.29 +eas SS (somatosensory primary + supplemen- 1.30 +tal), SSs (supplemental somatosensory), PIR (pir- 1.31 +iform), FRP (frontal pole), RSP (retrosplenial), 1.32 COApm (Cortical amygdalar, posterior part, me- 1.33 dial zone). Grouping some areas together, we 1.34 have also found genes to identify the groups